MGUS and smoldering multiple myeloma: update on pathogenesis, natural history, and management.
نویسنده
چکیده
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.
منابع مشابه
Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease.
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عنوان ژورنال:
- Hematology. American Society of Hematology. Education Program
دوره شماره
صفحات -
تاریخ انتشار 2005